ABSTRACT
Objective To investigate the value of the combined detection of NGAL ,CysC ,RBP and MMP‐2 in the diagnosis of type 2 diabetic nephropathy (T2DN) .Methods A total of 149 cases of type 2 diabetes mellitus(T2DM ) were divided into three groups according to the urine protein detection results :normal proteinuria group (NA group) ,micro proteinuria group (MA group) and clinical nephropathy group (CN group) .Contemporaneous 50 individuals undergoing healthy physical examination were selected as the control group (NC group) .The NGAL ,CysC ,RBP and MMP‐2 levels were analyzed and compared among 4 groups .Results The serum NGAL ,CysC and RBP levels in the NA group ,MA group and CN group were significantly higher than in the NC group (P<0 .05 or P<0 .01) ,while the MMP‐2 level was significantly lower than that in the NC group (P<0 .01) .The positive rate of combined detection of NGAL ,CysC ,RBP and MMP‐2 in the NA group ,MA group and CN group were 66 .0% ,85 .7% and 92% respectively ,which were higher than those of single detection (P<0 .05) .NGAL was positively correlated with CysC and RBP (P= 0 .05) and negatively correlated with MMP‐2 (P<0 .05) .Conclusion The serum levels of NGAL ,CysC ,RBP and MMP‐2 in the DN patients are significantly increased ,while the MMP‐2 level is significantlt decreased .Their combined detection can be used as an early monitoring and evaluation index of DN .
ABSTRACT
Objective To investigate the immunological feature, and to provide evidence for di-agnosis and treatment of POEMS syndrome. Methods The results detected with serum protein elec-trophoresis (SPE), immunofixation (IFE) and immunoglobulin quantitative assay were retrospectively compared and analyzed in 27 patients with POEMS syndrome. Results For 27 cases of POEMS syn-drome, the detection rate of M protein was significantly higher detected with IFE than that with SPE. Among M protein, IgA was much more frequent than IgG (16 cases vs 5 cases), and all were typeλ. Besides, there was statistical difference in SPE results between 16 cases of POEMS syndrome with M protein positive (detected with SPE) and healthy controls. Conclusion Negative M protein result can't exclude the diagnosis of POEMS syndrome. Further evidence should be searched for, and the clinical data should be emphasized